Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study

Divya Sabapathy; Jelena Klawitter; Lori Silveira; Ludmila Khailova; Max B. Mitchell; Gareth J. Morgan; Michael V. DiMaria; Mark Twite; Benjamin S. Frank; Jesse A. Davidson

doi:10.1007/s11306-020-01714-x

Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study

Divya Sabapathy
, Jelena Klawitter
, Lori Silveira
, Ludmila Khailova
, Max B. Mitchell
, Gareth J. Morgan
, Michael V. DiMaria
, Mark Twite
, Benjamin S. Frank
, Jesse A. Davidson

University of Colorado Anschutz Medical Campus

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed. Aims: To map changes in the KP induced by infant CPB. Methods: Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry. Results: Infant CPB results in marked increase in proximal, but not distal metabolites of the KP. Conclusions: Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.

Original language	English
Article number	93
Journal	Metabolomics
Volume	16
Issue number	9
DOIs	https://doi.org/10.1007/s11306-020-01714-x
State	Published - 1 Sep 2020
Externally published	Yes

Keywords

Bidirectional glenn
Congenital heart disease
Kynurenic acid
Quinolinic acid
Single ventricle palliation
Targeted metabolomics

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10.1007/s11306-020-01714-x

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Sabapathy, D., Klawitter, J., Silveira, L., Khailova, L., Mitchell, M. B., Morgan, G. J., DiMaria, M. V., Twite, M., Frank, B. S., & Davidson, J. A. (2020). Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study. Metabolomics, 16(9), Article 93. https://doi.org/10.1007/s11306-020-01714-x

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title = "Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study",

abstract = "Background: Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed. Aims: To map changes in the KP induced by infant CPB. Methods: Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry. Results: Infant CPB results in marked increase in proximal, but not distal metabolites of the KP. Conclusions: Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.",

keywords = "Bidirectional glenn, Congenital heart disease, Kynurenic acid, Quinolinic acid, Single ventricle palliation, Targeted metabolomics",

author = "Divya Sabapathy and Jelena Klawitter and Lori Silveira and Ludmila Khailova and Mitchell, \{Max B.\} and Morgan, \{Gareth J.\} and DiMaria, \{Michael V.\} and Mark Twite and Frank, \{Benjamin S.\} and Davidson, \{Jesse A.\}",

note = "Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2020",

month = sep,

day = "1",

doi = "10.1007/s11306-020-01714-x",

language = "English",

volume = "16",

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TY - JOUR

T1 - Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass

T2 - a prospective cohort study

AU - Sabapathy, Divya

AU - Klawitter, Jelena

AU - Silveira, Lori

AU - Khailova, Ludmila

AU - Mitchell, Max B.

AU - Morgan, Gareth J.

AU - DiMaria, Michael V.

AU - Twite, Mark

AU - Frank, Benjamin S.

AU - Davidson, Jesse A.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Background: Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed. Aims: To map changes in the KP induced by infant CPB. Methods: Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry. Results: Infant CPB results in marked increase in proximal, but not distal metabolites of the KP. Conclusions: Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.

AB - Background: Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed. Aims: To map changes in the KP induced by infant CPB. Methods: Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry. Results: Infant CPB results in marked increase in proximal, but not distal metabolites of the KP. Conclusions: Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.

KW - Bidirectional glenn

KW - Congenital heart disease

KW - Kynurenic acid

KW - Quinolinic acid

KW - Single ventricle palliation

KW - Targeted metabolomics

UR - https://www.scopus.com/pages/publications/85090216916

U2 - 10.1007/s11306-020-01714-x

DO - 10.1007/s11306-020-01714-x

M3 - Article

C2 - 32889608

AN - SCOPUS:85090216916

SN - 1573-3882

VL - 16

JO - Metabolomics

JF - Metabolomics

IS - 9

M1 - 93

ER -

Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study

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Keywords

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