Abstract
Infants requiring prolonged mechanical ventilation develop chronic respiratory problems. In addition to abnormalities in the lung parenchyma, airway injury with subsequent dysfunction is a hallmark of bronchopulmonary dysplasia. Developmental immaturity, in addition to ventilator-induced injury, predispose infants to significant limitations in overall pulmonary function. This review will focus on basic physiologic mechanics and clinical assessment of airways to elucidate the contribution of developmental and injury induced changes in the functional characteristics of airways.
| Original language | English |
|---|---|
| Pages (from-to) | 276-286 |
| Number of pages | 11 |
| Journal | New Horizons: Science and Practice of Acute Medicine |
| Volume | 7 |
| Issue number | 3 |
| State | Published - 1999 |
| Externally published | Yes |
Keywords
- Airway compliance
- Airway epithelium
- Airway reactivity
- Airway smooth muscle
- Bronchopulmonary dysplasia bronchoscopy
- Development
- Flow limitations
- Pharmacologic modulation
- Pulmonary function assessment
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