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Celiac disease and autoimmunity: Review and controversies

  • Nationwide Children’s Hospital
  • Ohio State University

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalCurrent Allergy and Asthma Reports
Volume13
Issue number4
DOIs
StatePublished - Aug 2013
Externally publishedYes

Keywords

  • Addison's
  • Addison's disease
  • Alopecia acreta
  • Antiphospholipid syndrome
  • Autoimmune
  • Autoimmune thyroiditis
  • Celiac
  • Celiac disease
  • Celiac hepatitis
  • Cryptogenic hepatitis
  • Dermatitis herpetiformis
  • Graves disease
  • Hashimoto's thyroiditis
  • Lupus
  • Primary biliary cirrhosis
  • Psoriasis
  • SLE
  • Sjogren's syndrome
  • Systemic lupus erythematous
  • Type 1 diabetes
  • Vitiligo

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