Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6

F. Bullrich; T. Druck; P. Kunapuli; J. Gomez; K. W. Gripp; B. Schlegelberger; J. Lasota; M. Aronson; L. A. Cannizzaro; K. Huebner; Jeffrey L. Benovic

doi:10.1159/000134045

Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6

F. Bullrich
, T. Druck
, P. Kunapuli
, J. Gomez
, K. W. Gripp
, B. Schlegelberger
, J. Lasota
, M. Aronson
, L. A. Cannizzaro
, K. Huebner
, Jeffrey L. Benovic

Thomas Jefferson University
Kiel University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRK5 (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24→qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter→q21.

Original language	English
Pages (from-to)	250-254
Number of pages	5
Journal	Cytogenetics and Cell Genetics
Volume	70
Issue number	3-4
DOIs	https://doi.org/10.1159/000134045
State	Published - 1995
Externally published	Yes

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title = "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6",

abstract = "G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRK5 (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24→qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter→q21.",

author = "F. Bullrich and T. Druck and P. Kunapuli and J. Gomez and Gripp, \{K. W.\} and B. Schlegelberger and J. Lasota and M. Aronson and Cannizzaro, \{L. A.\} and K. Huebner and Benovic, \{Jeffrey L.\}",

year = "1995",

doi = "10.1159/000134045",

language = "English",

volume = "70",

pages = "250--254",

journal = "Cytogenetics and Cell Genetics",

issn = "0301-0171",

publisher = "S. Karger AG",

number = "3-4",

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TY - JOUR

T1 - Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6

AU - Bullrich, F.

AU - Druck, T.

AU - Kunapuli, P.

AU - Gomez, J.

AU - Gripp, K. W.

AU - Schlegelberger, B.

AU - Lasota, J.

AU - Aronson, M.

AU - Cannizzaro, L. A.

AU - Huebner, K.

AU - Benovic, Jeffrey L.

PY - 1995

Y1 - 1995

N2 - G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRK5 (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24→qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter→q21.

AB - G protein-coupled receptor kinases (GRKs) play an important role in phosphorylating and regulating the activity of a variety of G protein-coupled receptors. Chromosomal mapping of the human genes for the two most recently identified members of the GRK family, GRK5 (GPRK5) and GRK6 (GPRK6), was accomplished by correlation of the presence of the GPRK5 and GPRK6 loci with specific chromosome regions in a rodent-human hybrid panel. These analyses revealed that GPRK5 maps to chromosome region 10q24→qter while GPRK6 maps to 5q35. A GPRK6 related locus maps to 13pter→q21.

UR - https://www.scopus.com/pages/publications/0029058473

U2 - 10.1159/000134045

DO - 10.1159/000134045

M3 - Article

C2 - 7789183

AN - SCOPUS:0029058473

SN - 0301-0171

VL - 70

SP - 250

EP - 254

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 3-4

ER -

Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6

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