Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group

doi:10.1016/j.jpeds.2022.07.033

Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group

University of California at Davis
Washington University St. Louis
Baylor College of Medicine
Harvard University
Ohio State University
Thomas Jefferson University
Northwestern University
University of Colorado Anschutz Medical Campus
University of Utah
University of Pennsylvania
Columbia University
Children's National Medical Center

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.

Original language	English
Pages (from-to)	100-104
Number of pages	5
Journal	Journal of Pediatrics
Volume	250
DOIs	https://doi.org/10.1016/j.jpeds.2022.07.033
State	Published - Nov 2022
Externally published	Yes

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10.1016/j.jpeds.2022.07.033

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title = "Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis",

abstract = "Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.",

author = "\{Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group\} and Glaser, \{Nicole S.\} and Quayle, \{Kimberly S.\} and McManemy, \{Julie K.\} and Nigrovic, \{Lise E.\} and Leah Tzimenatos and Stoner, \{Michael J.\} and Bennett, \{Jonathan E.\} and Trainor, \{Jennifer L.\} and Arleta Rewers and Schunk, \{Jeff E.\} and Myers, \{Sage R.\} and Kwok, \{Maria Y.\} and Brown, \{Kathleen M.\} and Simona Ghetti and Casper, \{T. Charles\} and Olsen, \{Cody S.\} and Nathan Kuppermann",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

month = nov,

doi = "10.1016/j.jpeds.2022.07.033",

language = "English",

volume = "250",

pages = "100--104",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

AU - Pediatric Emergency Care Applied Research Network (PECARN) DKA FLUID Study Group

AU - Glaser, Nicole S.

AU - Quayle, Kimberly S.

AU - McManemy, Julie K.

AU - Nigrovic, Lise E.

AU - Tzimenatos, Leah

AU - Stoner, Michael J.

AU - Bennett, Jonathan E.

AU - Trainor, Jennifer L.

AU - Rewers, Arleta

AU - Schunk, Jeff E.

AU - Myers, Sage R.

AU - Kwok, Maria Y.

AU - Brown, Kathleen M.

AU - Ghetti, Simona

AU - Casper, T. Charles

AU - Olsen, Cody S.

AU - Kuppermann, Nathan

PY - 2022/11

Y1 - 2022/11

N2 - Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.

AB - Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA treatment. We found that lower pH and higher BUN levels also were associated with cerebral injury at presentation.

UR - https://www.scopus.com/pages/publications/85136655283

U2 - 10.1016/j.jpeds.2022.07.033

DO - 10.1016/j.jpeds.2022.07.033

M3 - Article

C2 - 35944716

AN - SCOPUS:85136655283

SN - 0022-3476

VL - 250

SP - 100

EP - 104

JO - Journal of Pediatrics

JF - Journal of Pediatrics

ER -

Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis

Abstract

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