Congenital cytomegalovirus: Screening strategies and diagnostic challenges

Karen Ravin; Terri Stillwell

doi:10.1016/j.semperi.2026.152278

Congenital cytomegalovirus: Screening strategies and diagnostic challenges

Karen Ravin
, Terri Stillwell

Sidney Kimmel Medical College at Thomas Jefferson University
University of Pittsburgh School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Congenital cytomegalovirus (cCMV) infection is the most common congenital infection worldwide and a leading cause of sensorineural hearing loss (SNHL). Most newborns with cCMV will be asymptomatic at birth; however, a subset will go on to develop disease, including SNHL and neurodevelopmental problems, later in life. Given this, advocacy for newborn cCMV screening is growing. Targeted versus universal screening remains a hotly debated topic. This review will assess current diagnostic and screening modalities and explore unanswered questions.

Original language	English
Article number	152278
Pages (from-to)	152278
Journal	Seminars in Perinatology
Early online date	1 Jul 2026
DOIs	https://doi.org/10.1016/j.semperi.2026.152278
State	E-pub ahead of print - 1 Jul 2026

Keywords

Congenital cytomegalovirus
Hearing-targeted screening
Sensorineural hearing loss
Universal screening

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10.1016/j.semperi.2026.152278

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title = "Congenital cytomegalovirus: Screening strategies and diagnostic challenges",

abstract = "Congenital cytomegalovirus (cCMV) infection is the most common congenital infection worldwide and a leading cause of sensorineural hearing loss (SNHL). Most newborns with cCMV will be asymptomatic at birth; however, a subset will go on to develop disease, including SNHL and neurodevelopmental problems, later in life. Given this, advocacy for newborn cCMV screening is growing. Targeted versus universal screening remains a hotly debated topic. This review will assess current diagnostic and screening modalities and explore unanswered questions.",

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AU - Stillwell, Terri

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N2 - Congenital cytomegalovirus (cCMV) infection is the most common congenital infection worldwide and a leading cause of sensorineural hearing loss (SNHL). Most newborns with cCMV will be asymptomatic at birth; however, a subset will go on to develop disease, including SNHL and neurodevelopmental problems, later in life. Given this, advocacy for newborn cCMV screening is growing. Targeted versus universal screening remains a hotly debated topic. This review will assess current diagnostic and screening modalities and explore unanswered questions.

AB - Congenital cytomegalovirus (cCMV) infection is the most common congenital infection worldwide and a leading cause of sensorineural hearing loss (SNHL). Most newborns with cCMV will be asymptomatic at birth; however, a subset will go on to develop disease, including SNHL and neurodevelopmental problems, later in life. Given this, advocacy for newborn cCMV screening is growing. Targeted versus universal screening remains a hotly debated topic. This review will assess current diagnostic and screening modalities and explore unanswered questions.

KW - Congenital cytomegalovirus

KW - Hearing-targeted screening

KW - Sensorineural hearing loss

KW - Universal screening

UR - https://www.scopus.com/pages/publications/105043894610

U2 - 10.1016/j.semperi.2026.152278

DO - 10.1016/j.semperi.2026.152278

M3 - Review article

C2 - 42386471

SN - 0146-0005

SP - 152278

JO - Seminars in Perinatology

JF - Seminars in Perinatology

M1 - 152278

ER -

Congenital cytomegalovirus: Screening strategies and diagnostic challenges

Abstract

Keywords

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