TY - JOUR
T1 - COVID-19 in pediatric kidney transplantation
T2 - The Improving Renal Outcomes Collaborative
AU - Varnell, Charles
AU - Harshman, Lyndsay A.
AU - Smith, Laurie
AU - Liu, Chunyan
AU - Chen, Shiran
AU - Al-Akash, Samhar
AU - Barletta, Gina Marie
AU - Belsha, Craig
AU - Brakeman, Paul
AU - Chaudhuri, Abanti
AU - Fadakar, Paul
AU - Garro, Rouba
AU - Gluck, Caroline
AU - Goebel, Jens
AU - Kershaw, David
AU - Matossian, Debora
AU - Nailescu, Corina
AU - Patel, Hiren P.
AU - Pruette, Cozumel
AU - Ranabothu, Saritha
AU - Rodig, Nancy
AU - Smith, Jodi
AU - Sebestyen VanSickle, Judith
AU - Weng, Patricia
AU - Danziger-Isakov, Lara
AU - Hooper, David K.
AU - Seifert, Michael
N1 - Publisher Copyright:
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons
PY - 2021/8
Y1 - 2021/8
N2 - There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted a prospective cohort study through the Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome data about COVID-19 in pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing and outcomes data for 281 patients tested for SARS-CoV-2 by PCR. Testing indications included symptoms and/or potential exposures to COVID-19 (N = 134, 47.7%) and/or testing per hospital policy (N = 154, 54.8%). Overall, 24 (8.5%) patients tested positive, of which 15 (63%) were symptomatic. Of the COVID-19-positive patients, 16 were managed as outpatients, six received non-ICU inpatient care and two were admitted to the ICU. There were no episodes of respiratory failure, allograft loss, or death associated with COVID-19. To estimate incidence, subanalysis was performed for 13 centers that care for 1686 patients that submitted all negative and positive COVID-19 results. Of the 229 tested patients at these 13 centers, 10 (5 asymptomatic) patients tested positive, yielding an overall incidence of 0.6% and an incidence among tested patients of 4.4%. Pediatric KT patients in the United States had a low estimated incidence of COVID-19 disease and excellent short-term outcomes.
AB - There are limited data on the impact of COVID-19 in children with a kidney transplant (KT). We conducted a prospective cohort study through the Improving Renal Outcomes Collaborative (IROC) to collect clinical outcome data about COVID-19 in pediatric KT patients. Twenty-two IROC centers that care for 2732 patients submitted testing and outcomes data for 281 patients tested for SARS-CoV-2 by PCR. Testing indications included symptoms and/or potential exposures to COVID-19 (N = 134, 47.7%) and/or testing per hospital policy (N = 154, 54.8%). Overall, 24 (8.5%) patients tested positive, of which 15 (63%) were symptomatic. Of the COVID-19-positive patients, 16 were managed as outpatients, six received non-ICU inpatient care and two were admitted to the ICU. There were no episodes of respiratory failure, allograft loss, or death associated with COVID-19. To estimate incidence, subanalysis was performed for 13 centers that care for 1686 patients that submitted all negative and positive COVID-19 results. Of the 229 tested patients at these 13 centers, 10 (5 asymptomatic) patients tested positive, yielding an overall incidence of 0.6% and an incidence among tested patients of 4.4%. Pediatric KT patients in the United States had a low estimated incidence of COVID-19 disease and excellent short-term outcomes.
KW - clinical research/practice
KW - epidemiology
KW - health services and outcomes research
KW - infection and infectious agents
KW - infectious disease
KW - kidney transplantation/nephrology
KW - pediatrics
UR - https://www.scopus.com/pages/publications/85100832679
U2 - 10.1111/ajt.16501
DO - 10.1111/ajt.16501
M3 - Article
C2 - 33452854
AN - SCOPUS:85100832679
SN - 1600-6135
VL - 21
SP - 2740
EP - 2748
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 8
ER -