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Delayed Effect After Procedural Sedation With Oral Ketamine and Midazolam

  • The Children's Hospital of Philadelphia

Research output: Contribution to journal › Article › peer-review

Abstract

In 2025, we reported our experience with the following regimen for pediatric ED procedural sedation: 6 mg/kg oral (PO) ketamine (max 200 mg) and 0.5 mg/kg PO midazolam (max 15 mg). We present 2 children who received this regimen with respiratory depression after apparent recovery. PO ketamine and midazolam may cause a delayed sedative effect, which may limit its usefulness.

Original languageEnglish
JournalPediatric Emergency Care
VolumePublish Ahead of Print
DOIs
StatePublished - 2025

Keywords

  • ketamine
  • oral medication
  • sedation

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