Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

Mark W. Russell; Julie S. Moldenhauer; Jack Rychik; Nancy B. Burnham; Erin Zullo; Samuel I. Parry; Rebecca A. Simmons; Michal A. Elovitz; Susan C. Nicolson; Rebecca L. Linn; Mark P. Johnson; Sunkyung Yu; Matthew G. Sampson; H. Hakonarson; J. William Gaynor

doi:10.1016/j.dib.2019.104311

Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

Mark W. Russell
, Julie S. Moldenhauer
, Jack Rychik
, Nancy B. Burnham
, Erin Zullo
, Samuel I. Parry
, Rebecca A. Simmons
, Michal A. Elovitz
, Susan C. Nicolson
, Rebecca L. Linn
, Mark P. Johnson
, Sunkyung Yu
, Matthew G. Sampson
, H. Hakonarson
, J. William Gaynor

University of Michigan, Ann Arbor
The Children's Hospital of Philadelphia
University of Pennsylvania

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019).

Original language	English
Article number	104311
Journal	Data in Brief
Volume	25
DOIs	https://doi.org/10.1016/j.dib.2019.104311
State	Published - Aug 2019
Externally published	Yes

Keywords

Congenital cardiac defects
Fetal growth
Genetic variation
Placental function

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10.1016/j.dib.2019.104311

Cite this

Russell, M. W., Moldenhauer, J. S., Rychik, J., Burnham, N. B., Zullo, E., Parry, S. I., Simmons, R. A., Elovitz, M. A., Nicolson, S. C., Linn, R. L., Johnson, M. P., Yu, S., Sampson, M. G., Hakonarson, H., & Gaynor, J. W. (2019). Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses. Data in Brief, 25, Article 104311. https://doi.org/10.1016/j.dib.2019.104311

@article{b9270538eea649fe9f4545022857ff24,

title = "Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses",

abstract = "The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article {\textquotedblleft}Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects{\textquotedblright} (Russell et al., 2019).",

keywords = "Congenital cardiac defects, Fetal growth, Genetic variation, Placental function",

author = "Russell, \{Mark W.\} and Moldenhauer, \{Julie S.\} and Jack Rychik and Burnham, \{Nancy B.\} and Erin Zullo and Parry, \{Samuel I.\} and Simmons, \{Rebecca A.\} and Elovitz, \{Michal A.\} and Nicolson, \{Susan C.\} and Linn, \{Rebecca L.\} and Johnson, \{Mark P.\} and Sunkyung Yu and Sampson, \{Matthew G.\} and H. Hakonarson and Gaynor, \{J. William\}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = aug,

doi = "10.1016/j.dib.2019.104311",

language = "English",

volume = "25",

journal = "Data in Brief",

issn = "2352-3409",

publisher = "Elsevier Inc.",

}

Russell, MW, Moldenhauer, JS, Rychik, J, Burnham, NB, Zullo, E, Parry, SI, Simmons, RA, Elovitz, MA, Nicolson, SC, Linn, RL, Johnson, MP, Yu, S, Sampson, MG, Hakonarson, H & Gaynor, JW 2019, 'Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses', Data in Brief, vol. 25, 104311. https://doi.org/10.1016/j.dib.2019.104311

TY - JOUR

T1 - Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects

T2 - Data and analyses

AU - Russell, Mark W.

AU - Moldenhauer, Julie S.

AU - Rychik, Jack

AU - Burnham, Nancy B.

AU - Zullo, Erin

AU - Parry, Samuel I.

AU - Simmons, Rebecca A.

AU - Elovitz, Michal A.

AU - Nicolson, Susan C.

AU - Linn, Rebecca L.

AU - Johnson, Mark P.

AU - Yu, Sunkyung

AU - Sampson, Matthew G.

AU - Hakonarson, H.

AU - Gaynor, J. William

PY - 2019/8

Y1 - 2019/8

N2 - The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019).

AB - The placenta is a highly vascular structure composed of both maternal and fetal elements. We have determined that damaging variants in genes responsible for the positive regulation of angiogenesis (PRA) (GO:0045766) that are inherited by the fetus impair fetal growth and placental function in pregnancies involving critical congenital cardiac defects (Russell et al., 2019). In this dataset, we present the specific genetic variants identified, describe the parental origin of each variant where possible and present the analyses regarding the potential effects of parental origin of the variant on placental function and fetal growth. The data presented are related to the research article “Damaging variants in pro-angiogenic genes impair growth in fetuses with cardiac defects” (Russell et al., 2019).

KW - Congenital cardiac defects

KW - Fetal growth

KW - Genetic variation

KW - Placental function

UR - https://www.scopus.com/pages/publications/85070205832

U2 - 10.1016/j.dib.2019.104311

DO - 10.1016/j.dib.2019.104311

M3 - Article

AN - SCOPUS:85070205832

SN - 2352-3409

VL - 25

JO - Data in Brief

JF - Data in Brief

M1 - 104311

ER -

Effect of parental origin of damaging variants in pro-angiogenic genes on fetal growth in patients with congenital heart defects: Data and analyses

Abstract

Keywords

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