Hyperoxia causes MIR-34a-mediated injury via angiopoietin-1 in neonatal lungs

Mansoor Syed; Pragnya Das; Aishwarya Pawar; Zubair H. Aghai; Anu Kaskinen; Zhen W. Zhuang; Namasivayam Ambalavanan; Gloria Pryhuber; Sture Andersson; Vineet Bhandari

doi:10.1038/s41467-017-01349-y

Hyperoxia causes MIR-34a-mediated injury via angiopoietin-1 in neonatal lungs

Mansoor Syed
, Pragnya Das
, Aishwarya Pawar
, Zubair H. Aghai
, Anu Kaskinen
, Zhen W. Zhuang
, Namasivayam Ambalavanan
, Gloria Pryhuber
, Sture Andersson
, Vineet Bhandari

Yale University
Drexel University
Jamia Millia Islamia
Children's Hospital Helsinki
Division of Neonatology
University of Rochester

Research output: Contribution to journal › Article › peer-review

121 Scopus citations

Abstract

Hyperoxia contributes to lung injury in bronchopulmonary dysplasia. The authors show that hyperoxia increases miR-34a expression in human neonates and in mouse models, and that pathology is ameliorated by miR-34a inhibition or by administration of its target angiopoietin-1.

Original language	English
Article number	1173
Journal	Nature Communications
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41467-017-01349-y
State	Published - 1 Dec 2017

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title = "Hyperoxia causes MIR-34a-mediated injury via angiopoietin-1 in neonatal lungs",

abstract = "Hyperoxia contributes to lung injury in bronchopulmonary dysplasia. The authors show that hyperoxia increases miR-34a expression in human neonates and in mouse models, and that pathology is ameliorated by miR-34a inhibition or by administration of its target angiopoietin-1.",

author = "Mansoor Syed and Pragnya Das and Aishwarya Pawar and Aghai, \{Zubair H.\} and Anu Kaskinen and Zhuang, \{Zhen W.\} and Namasivayam Ambalavanan and Gloria Pryhuber and Sture Andersson and Vineet Bhandari",

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AU - Syed, Mansoor

AU - Das, Pragnya

AU - Pawar, Aishwarya

AU - Aghai, Zubair H.

AU - Kaskinen, Anu

AU - Zhuang, Zhen W.

AU - Ambalavanan, Namasivayam

AU - Pryhuber, Gloria

AU - Andersson, Sture

AU - Bhandari, Vineet

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Hyperoxia contributes to lung injury in bronchopulmonary dysplasia. The authors show that hyperoxia increases miR-34a expression in human neonates and in mouse models, and that pathology is ameliorated by miR-34a inhibition or by administration of its target angiopoietin-1.

AB - Hyperoxia contributes to lung injury in bronchopulmonary dysplasia. The authors show that hyperoxia increases miR-34a expression in human neonates and in mouse models, and that pathology is ameliorated by miR-34a inhibition or by administration of its target angiopoietin-1.

UR - https://www.scopus.com/pages/publications/85032511753

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DO - 10.1038/s41467-017-01349-y

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VL - 8

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Hyperoxia causes MIR-34a-mediated injury via angiopoietin-1 in neonatal lungs

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