Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

Douglas J. Harrison; Jonathan D. Gill; Michael E. Roth; Wendong Zhang; Beverly Teicher; Stephen Erickson; Greg Gatto; Raushan T. Kurmasheva; Peter J. Houghton; Malcolm A. Smith; Edward Anders Kolb; Richard Gorlick

doi:10.1002/pbc.28222

Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

Douglas J. Harrison
, Jonathan D. Gill
, Michael E. Roth
, Wendong Zhang
, Beverly Teicher
, Stephen Erickson
, Greg Gatto
, Raushan T. Kurmasheva
, Peter J. Houghton
, Malcolm A. Smith
, Edward Anders Kolb
, Richard Gorlick

University of Texas MD Anderson Cancer Center
National Institutes of Health
RTI International
University of Texas Health Science Center at San Antonio
Alfred I. duPont Hospital for Children

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.

Original language	English
Article number	e28222
Journal	Pediatric Blood and Cancer
Volume	67
Issue number	6
DOIs	https://doi.org/10.1002/pbc.28222
State	Published - 1 Jun 2020
Externally published	Yes

Keywords

Ewing sarcoma
multitarget kinase inhibitor
osteosarcoma
patient derived xenograft
pediatric preclinical testing consortium
rhabdomyosarcoma

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10.1002/pbc.28222

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Harrison, D. J., Gill, J. D., Roth, M. E., Zhang, W., Teicher, B., Erickson, S., Gatto, G., Kurmasheva, R. T., Houghton, P. J., Smith, M. A., Kolb, E. A., & Gorlick, R. (2020). Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium. Pediatric Blood and Cancer, 67(6), Article e28222. https://doi.org/10.1002/pbc.28222

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title = "Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium",

abstract = "Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.",

keywords = "Ewing sarcoma, multitarget kinase inhibitor, osteosarcoma, patient derived xenograft, pediatric preclinical testing consortium, rhabdomyosarcoma",

author = "Harrison, \{Douglas J.\} and Gill, \{Jonathan D.\} and Roth, \{Michael E.\} and Wendong Zhang and Beverly Teicher and Stephen Erickson and Greg Gatto and Kurmasheva, \{Raushan T.\} and Houghton, \{Peter J.\} and Smith, \{Malcolm A.\} and Kolb, \{Edward Anders\} and Richard Gorlick",

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year = "2020",

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doi = "10.1002/pbc.28222",

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T1 - Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

AU - Harrison, Douglas J.

AU - Gill, Jonathan D.

AU - Roth, Michael E.

AU - Zhang, Wendong

AU - Teicher, Beverly

AU - Erickson, Stephen

AU - Gatto, Greg

AU - Kurmasheva, Raushan T.

AU - Houghton, Peter J.

AU - Smith, Malcolm A.

AU - Kolb, Edward Anders

AU - Gorlick, Richard

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.

AB - Background: Regorafenib is a small molecule multikinase inhibitor that inhibits multiple kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1-3. Procedures: The in vivo anticancer effects of regorafenib were assessed in a panel of six osteosarcoma models, three rhabdomyosarcoma models, and one Ewing sarcoma model. Results: Regorafenib induced modest inhibition of tumor growth in the models evaluated. Conclusion: The overall pattern of response to regorafenib appears similar to that of the kinase inhibitor sorafenib, with pronounced slowing of tumor growth in some models, limited to the period of agent administration, being the primary treatment effect.

KW - Ewing sarcoma

KW - multitarget kinase inhibitor

KW - osteosarcoma

KW - patient derived xenograft

KW - pediatric preclinical testing consortium

KW - rhabdomyosarcoma

UR - https://www.scopus.com/pages/publications/85082815577

U2 - 10.1002/pbc.28222

DO - 10.1002/pbc.28222

M3 - Article

C2 - 32207565

AN - SCOPUS:85082815577

SN - 1545-5009

VL - 67

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 6

M1 - e28222

ER -

Initial in vivo testing of a multitarget kinase inhibitor, regorafenib, by the Pediatric Preclinical Testing Consortium

Abstract

Keywords

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