Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs)

on behalf of the Palliative Care and Ethics Focus Group of the Children’s Hospital Neonatal Consortium (CHNC)

doi:10.1038/s41372-021-01111-9

Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs)

on behalf of the Palliative Care and Ethics Focus Group of the Children’s Hospital Neonatal Consortium (CHNC)

Medical College of Wisconsin
Children's Hospital of Wisconsin Wauwatosa
Children's Hospital Association
Indiana University-Purdue University Indianapolis
Riley Hospital for Children
University of Pittsburgh
University of Alabama at Birmingham
Division of Neonatology
Northwestern University
Children's Memorial Hospital
University of Central Florida
Division of Neonatology at Advent Health for Children
University of Washington
Seattle Children's
University of Utah
Division of Neonatology at Primary Children’s Hospital
Central Michigan University
Children's Hospital of Michigan
University of Texas Southwestern Medical Center
Children's Medical Center Dallas
Ohio State University
Nationwide Children’s Hospital
Primary Children's Medical Center
University of California at Irvine
University of Missouri at Kansas City
Children's Mercy Hospitals and Clinics
Emory University
Children's Healthcare of Atlanta
Harvard University
Boston Children's Hospital
Thomas Jefferson University
Alfred I. duPont Hospital for Children
Children's Healthcare of Atlanta at Scottish Rite
Alabama Children's Hospital
Le Bonheur Children’s Hospital
Cincinnati Children's Hospital Medical Center
Children’s Hospital Colorado
Cook Children's Health Care System
Texas Children's Hospital Houston
University of Arkansas for Medical Sciences
Children's Hospital Los Angeles
University of Wisconsin-Madison
UCSF Benioff Children's Hospital Oakland
The Children's Hospital of Philadelphia
St. Christopher's Hospital for Children
Washington University St. Louis
Johns Hopkins University
Rady Children's Hospital
Children's National Medical Center
Children's Hospital of Omaha
AdventHealth Orlando
University of Toronto

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Objectives: To examine characteristics and outcomes of T18 and T13 infants receiving intensive surgical and medical treatment compared to those receiving non-intensive treatment in NICUs. Study design: Retrospective cohort of infants in the Children’s Hospitals National Consortium (CHNC) from 2010 to 2016 categorized into three groups by treatment received: surgical, intensive medical, or non-intensive. Results: Among 467 infants admitted, 62% received intensive medical treatment; 27% received surgical treatment. The most common surgery was a gastrostomy tube. Survival in infants who received surgeries was 51%; intensive medical treatment was 30%, and non-intensive treatment was 72%. Infants receiving surgeries spent more time in the NICU and were more likely to receive oxygen and feeding support at discharge. Conclusions: Infants with T13 or T18 at CHNC NICUs represent a select group for whom parents may have desired more intensive treatment. Survival to NICU discharge was possible, and surviving infants had a longer hospital stay and needed more discharge supports.

Original language	English
Pages (from-to)	1745-1754
Number of pages	10
Journal	Journal of Perinatology
Volume	41
Issue number	7
DOIs	https://doi.org/10.1038/s41372-021-01111-9
State	Published - Jul 2021
Externally published	Yes

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10.1038/s41372-021-01111-9

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on behalf of the Palliative Care and Ethics Focus Group of the Children’s Hospital Neonatal Consortium (CHNC) (2021). Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs). Journal of Perinatology, 41(7), 1745-1754. https://doi.org/10.1038/s41372-021-01111-9

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title = "Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children{\textquoteright}s hospitals neonatal intensive care units (NICUs)",

abstract = "Objectives: To examine characteristics and outcomes of T18 and T13 infants receiving intensive surgical and medical treatment compared to those receiving non-intensive treatment in NICUs. Study design: Retrospective cohort of infants in the Children{\textquoteright}s Hospitals National Consortium (CHNC) from 2010 to 2016 categorized into three groups by treatment received: surgical, intensive medical, or non-intensive. Results: Among 467 infants admitted, 62\% received intensive medical treatment; 27\% received surgical treatment. The most common surgery was a gastrostomy tube. Survival in infants who received surgeries was 51\%; intensive medical treatment was 30\%, and non-intensive treatment was 72\%. Infants receiving surgeries spent more time in the NICU and were more likely to receive oxygen and feeding support at discharge. Conclusions: Infants with T13 or T18 at CHNC NICUs represent a select group for whom parents may have desired more intensive treatment. Survival to NICU discharge was possible, and surviving infants had a longer hospital stay and needed more discharge supports.",

author = "\{on behalf of the Palliative Care and Ethics Focus Group of the Children{\textquoteright}s Hospital Neonatal Consortium (CHNC)\} and Krishna Acharya and Leuthner, \{Steven R.\} and Isabella Zaniletti and Niehaus, \{Jason Z.\} and Bishop, \{Christine E.\} and Coghill, \{Carl H.\} and Ankur Datta and Narendra Dereddy and Robert DiGeronimo and Laura Jackson and Ling, \{Con Yee\} and Nana Matoba and Girija Natarajan and Nayak, \{Sujir Pritha\} and Schlegel, \{Amy Brown\} and Jamie Seale and Anita Shah and Julie Weiner and Williams, \{Helen O.\} and Wojcik, \{Monica H.\} and Fry, \{Jessica T.\} and Kevin Sullivan and Anthony Piazza and Gregory Sysyn and Carl Coghill and Ajay Talati and Anne Hansen and Tanzeema Houssain and Karna Murthy and Gustave Falciglia and Beth Haberman and Kristina Reber and Rashmin Savani and Theresa Grover and Girija Natarajan and Annie Chi and Yvette Johnson and Gautham Suresh and William Engle and Eugenia Pallotto and Robert Lyle and Becky Rogers and Rachel Chapman and Jamie Limjoco and Priscilla Joe and Jacquelyn Evans and Michael Padula and David Munson and Suzanne Touch and Beverly Brozanski",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

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doi = "10.1038/s41372-021-01111-9",

language = "English",

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on behalf of the Palliative Care and Ethics Focus Group of the Children’s Hospital Neonatal Consortium (CHNC) 2021, 'Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs)', Journal of Perinatology, vol. 41, no. 7, pp. 1745-1754. https://doi.org/10.1038/s41372-021-01111-9

Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs). / on behalf of the Palliative Care and Ethics Focus Group of the Children’s Hospital Neonatal Consortium (CHNC).
In: Journal of Perinatology, Vol. 41, No. 7, 07.2021, p. 1745-1754.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs)

AU - on behalf of the Palliative Care and Ethics Focus Group of the Children’s Hospital Neonatal Consortium (CHNC)

AU - Acharya, Krishna

AU - Leuthner, Steven R.

AU - Zaniletti, Isabella

AU - Niehaus, Jason Z.

AU - Bishop, Christine E.

AU - Coghill, Carl H.

AU - Datta, Ankur

AU - Dereddy, Narendra

AU - DiGeronimo, Robert

AU - Jackson, Laura

AU - Ling, Con Yee

AU - Matoba, Nana

AU - Natarajan, Girija

AU - Nayak, Sujir Pritha

AU - Schlegel, Amy Brown

AU - Seale, Jamie

AU - Shah, Anita

AU - Weiner, Julie

AU - Williams, Helen O.

AU - Wojcik, Monica H.

AU - Fry, Jessica T.

AU - Sullivan, Kevin

AU - Piazza, Anthony

AU - Sysyn, Gregory

AU - Coghill, Carl

AU - Talati, Ajay

AU - Hansen, Anne

AU - Houssain, Tanzeema

AU - Murthy, Karna

AU - Falciglia, Gustave

AU - Haberman, Beth

AU - Reber, Kristina

AU - Savani, Rashmin

AU - Grover, Theresa

AU - Natarajan, Girija

AU - Chi, Annie

AU - Johnson, Yvette

AU - Suresh, Gautham

AU - Engle, William

AU - Pallotto, Eugenia

AU - Lyle, Robert

AU - Rogers, Becky

AU - Chapman, Rachel

AU - Limjoco, Jamie

AU - Joe, Priscilla

AU - Evans, Jacquelyn

AU - Padula, Michael

AU - Munson, David

AU - Touch, Suzanne

AU - Brozanski, Beverly

PY - 2021/7

Y1 - 2021/7

N2 - Objectives: To examine characteristics and outcomes of T18 and T13 infants receiving intensive surgical and medical treatment compared to those receiving non-intensive treatment in NICUs. Study design: Retrospective cohort of infants in the Children’s Hospitals National Consortium (CHNC) from 2010 to 2016 categorized into three groups by treatment received: surgical, intensive medical, or non-intensive. Results: Among 467 infants admitted, 62% received intensive medical treatment; 27% received surgical treatment. The most common surgery was a gastrostomy tube. Survival in infants who received surgeries was 51%; intensive medical treatment was 30%, and non-intensive treatment was 72%. Infants receiving surgeries spent more time in the NICU and were more likely to receive oxygen and feeding support at discharge. Conclusions: Infants with T13 or T18 at CHNC NICUs represent a select group for whom parents may have desired more intensive treatment. Survival to NICU discharge was possible, and surviving infants had a longer hospital stay and needed more discharge supports.

AB - Objectives: To examine characteristics and outcomes of T18 and T13 infants receiving intensive surgical and medical treatment compared to those receiving non-intensive treatment in NICUs. Study design: Retrospective cohort of infants in the Children’s Hospitals National Consortium (CHNC) from 2010 to 2016 categorized into three groups by treatment received: surgical, intensive medical, or non-intensive. Results: Among 467 infants admitted, 62% received intensive medical treatment; 27% received surgical treatment. The most common surgery was a gastrostomy tube. Survival in infants who received surgeries was 51%; intensive medical treatment was 30%, and non-intensive treatment was 72%. Infants receiving surgeries spent more time in the NICU and were more likely to receive oxygen and feeding support at discharge. Conclusions: Infants with T13 or T18 at CHNC NICUs represent a select group for whom parents may have desired more intensive treatment. Survival to NICU discharge was possible, and surviving infants had a longer hospital stay and needed more discharge supports.

UR - https://www.scopus.com/pages/publications/85107536418

U2 - 10.1038/s41372-021-01111-9

DO - 10.1038/s41372-021-01111-9

M3 - Article

C2 - 34112961

AN - SCOPUS:85107536418

SN - 0743-8346

VL - 41

SP - 1745

EP - 1754

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 7

ER -

Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs)

Abstract

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