TY - JOUR
T1 - Multisystem Inflammatory Syndrome in Children
T2 - Survey of Protocols for Early Hospital Evaluation and Management
AU - Dove, Matthew L.
AU - Jaggi, Preeti
AU - Kelleman, Michael
AU - Abuali, Mayssa
AU - Ang, Jocelyn Y.
AU - Ballan, Wassim
AU - Basu, Sanmit K.
AU - Campbell, M. Jay
AU - Chikkabyrappa, Sathish M.
AU - Choueiter, Nadine F.
AU - Clouser, Katharine N.
AU - Corwin, Daniel
AU - Edwards, Amy
AU - Gertz, Shira J.
AU - Ghassemzadeh, Rod
AU - Jarrah, Rima J.
AU - Katz, Sophie E.
AU - Knutson, Stacie M.
AU - Kuebler, Joseph D.
AU - Lighter, Jennifer
AU - Mikesell, Christine
AU - Mongkolrattanothai, Kanokporn
AU - Morton, Ted
AU - Nakra, Natasha A.
AU - Olivero, Rosemary
AU - Osborne, Christina M.
AU - Panesar, Laurie E.
AU - Parsons, Sarah
AU - Patel, Rupal M.
AU - Schuette, Jennifer
AU - Thacker, Deepika
AU - Tremoulet, Adriana H.
AU - Vidwan, Navjyot K.
AU - Oster, Matthew E.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2021/2
Y1 - 2021/2
N2 - Objective: To describe the similarities and differences in the evaluation and treatment of multisystem inflammatory syndrome in children (MIS-C) at hospitals in the US. Study design: We conducted a cross-sectional survey from June 16 to July 16, 2020, of US children's hospitals regarding protocols for management of patients with MIS-C. Elements included characteristics of the hospital, clinical definition of MIS-C, evaluation, treatment, and follow-up. We summarized key findings and compared results from centers in which >5 patients had been treated vs those in which ≤5 patients had been treated. Results: In all, 40 centers of varying size and experience with MIS-C participated in this protocol survey. Overall, 21 of 40 centers required only 1 day of fever for MIS-C to be considered. In the evaluation of patients, there was often a tiered approach. Intravenous immunoglobulin was the most widely recommended medication to treat MIS-C (98% of centers). Corticosteroids were listed in 93% of protocols primarily for moderate or severe cases. Aspirin was commonly recommended for mild cases, whereas heparin or low molecular weight heparin were to be used primarily in severe cases. In severe cases, anakinra and vasopressors frequently were recommended; 39 of 40 centers recommended follow-up with cardiology. There were similar findings between centers in which >5 patients vs ≤5 patients had been managed. Supplemental materials containing hospital protocols are provided. Conclusions: There are many similarities yet key differences between hospital protocols for MIS-C. These findings can help healthcare providers learn from others regarding options for managing MIS-C.
AB - Objective: To describe the similarities and differences in the evaluation and treatment of multisystem inflammatory syndrome in children (MIS-C) at hospitals in the US. Study design: We conducted a cross-sectional survey from June 16 to July 16, 2020, of US children's hospitals regarding protocols for management of patients with MIS-C. Elements included characteristics of the hospital, clinical definition of MIS-C, evaluation, treatment, and follow-up. We summarized key findings and compared results from centers in which >5 patients had been treated vs those in which ≤5 patients had been treated. Results: In all, 40 centers of varying size and experience with MIS-C participated in this protocol survey. Overall, 21 of 40 centers required only 1 day of fever for MIS-C to be considered. In the evaluation of patients, there was often a tiered approach. Intravenous immunoglobulin was the most widely recommended medication to treat MIS-C (98% of centers). Corticosteroids were listed in 93% of protocols primarily for moderate or severe cases. Aspirin was commonly recommended for mild cases, whereas heparin or low molecular weight heparin were to be used primarily in severe cases. In severe cases, anakinra and vasopressors frequently were recommended; 39 of 40 centers recommended follow-up with cardiology. There were similar findings between centers in which >5 patients vs ≤5 patients had been managed. Supplemental materials containing hospital protocols are provided. Conclusions: There are many similarities yet key differences between hospital protocols for MIS-C. These findings can help healthcare providers learn from others regarding options for managing MIS-C.
UR - https://www.scopus.com/pages/publications/85096381668
U2 - 10.1016/j.jpeds.2020.10.026
DO - 10.1016/j.jpeds.2020.10.026
M3 - Article
C2 - 33075369
AN - SCOPUS:85096381668
SN - 0022-3476
VL - 229
SP - 33
EP - 40
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -