Possible transmission of parvovirus B19 from intravenous immune globulin

Dean D. Erdman; Barbara C. Anderson; Thomas J. Török; Terri H. Finkel; Larry J. Anderson

doi:10.1002/(SICI)1096-9071(199711)53:3<233::AID-JMV9>3.0.CO;2-9

Possible transmission of parvovirus B19 from intravenous immune globulin

Dean D. Erdman
, Barbara C. Anderson
, Thomas J. Török
, Terri H. Finkel
, Larry J. Anderson

Centers for Disease Control and Prevention
National Jewish Medical and Research Center

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

To look for genetic changes in human parvovirus B19 that might be associated with chronic infection, we sequenced B19 DNA obtained from serum specimens collected over an approximately 1-year period from a patient with systemic vasculitis. A comparison of the nucleotide sequences of the VP1/VP2 gene four specimens revealed an abrupt change in the B19 genotype that coincide with initiation of intravenous immune globulin (IVIG) therapy. We suspect that one or more of the lots of IVIG administered to the patient were contaminated with B19. If true, this finding suggests that investigators must be careful in linking B19 infection to disease based on detection of B19 DNA in persons who have received multiple unit blood products.

Original language	English
Pages (from-to)	233-236
Number of pages	4
Journal	Journal of Medical Virology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1002/(SICI)1096-9071(199711)53:3<233::AID-JMV9>3.0.CO;2-9
State	Published - Nov 1997
Externally published	Yes

Keywords

Blood products
Chronic B19 infection
PCR

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10.1002/(SICI)1096-9071(199711)53:3<233::AID-JMV9>3.0.CO;2-9

Cite this

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title = "Possible transmission of parvovirus B19 from intravenous immune globulin",

abstract = "To look for genetic changes in human parvovirus B19 that might be associated with chronic infection, we sequenced B19 DNA obtained from serum specimens collected over an approximately 1-year period from a patient with systemic vasculitis. A comparison of the nucleotide sequences of the VP1/VP2 gene four specimens revealed an abrupt change in the B19 genotype that coincide with initiation of intravenous immune globulin (IVIG) therapy. We suspect that one or more of the lots of IVIG administered to the patient were contaminated with B19. If true, this finding suggests that investigators must be careful in linking B19 infection to disease based on detection of B19 DNA in persons who have received multiple unit blood products.",

keywords = "Blood products, Chronic B19 infection, PCR",

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AU - Erdman, Dean D.

AU - Anderson, Barbara C.

AU - Török, Thomas J.

AU - Finkel, Terri H.

AU - Anderson, Larry J.

PY - 1997/11

Y1 - 1997/11

N2 - To look for genetic changes in human parvovirus B19 that might be associated with chronic infection, we sequenced B19 DNA obtained from serum specimens collected over an approximately 1-year period from a patient with systemic vasculitis. A comparison of the nucleotide sequences of the VP1/VP2 gene four specimens revealed an abrupt change in the B19 genotype that coincide with initiation of intravenous immune globulin (IVIG) therapy. We suspect that one or more of the lots of IVIG administered to the patient were contaminated with B19. If true, this finding suggests that investigators must be careful in linking B19 infection to disease based on detection of B19 DNA in persons who have received multiple unit blood products.

AB - To look for genetic changes in human parvovirus B19 that might be associated with chronic infection, we sequenced B19 DNA obtained from serum specimens collected over an approximately 1-year period from a patient with systemic vasculitis. A comparison of the nucleotide sequences of the VP1/VP2 gene four specimens revealed an abrupt change in the B19 genotype that coincide with initiation of intravenous immune globulin (IVIG) therapy. We suspect that one or more of the lots of IVIG administered to the patient were contaminated with B19. If true, this finding suggests that investigators must be careful in linking B19 infection to disease based on detection of B19 DNA in persons who have received multiple unit blood products.

KW - Blood products

KW - Chronic B19 infection

KW - PCR

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ER -

Possible transmission of parvovirus B19 from intravenous immune globulin

Abstract

Keywords

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