Previous SARS-CoV-2 Infection Is Not Associated with Increased Celiac Disease Autoimmunity in Children and Adolescents

Michelle M. Corrado; Xiaofan Jia; Cristy Geno Rasmussen; Laura Pyle; Liping Yu; Edwin Liu; Marisa Stahl; Marian J. Rewers

doi:10.14309/ajg.0000000000002317

Previous SARS-CoV-2 Infection Is Not Associated with Increased Celiac Disease Autoimmunity in Children and Adolescents

Michelle M. Corrado
, Xiaofan Jia
, Cristy Geno Rasmussen
, Laura Pyle
, Liping Yu
, Edwin Liu
, Marisa Stahl
, Marian J. Rewers

The Children's Hospital, Aurora
Barbara Davis Center for Childhood Diabetes

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

INTRODUCTION:Recent reports suggest severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections may increase the risk of celiac disease autoimmunity. This study aims to evaluate potential associations between coronavirus disease 2019 infection and tissue transglutaminase autoantibodies (TGA) immunoglobulin A.METHODS:From 2020 to 2021, cross-sectional screening for SARS-CoV-2 antibodies and TGA was offered to 4,717 children in Colorado through the Autoimmunity Screening for Kids study. Multivariable logistic regression assessed association between previous SARS-CoV-2 infection and TGA positivity.RESULTS:Previous SARS-CoV-2 infection was not associated with TGA positivity (odds ratio 1.02, 95% confidence interval 0.63-1.59; P = 0.95).DISCUSSION:In this large-scale analysis, previous SARS-CoV-2 infection was not associated with celiac disease autoimmunity in Colorado children.

Original language	English
Pages (from-to)	1698-1700
Number of pages	3
Journal	American Journal of Gastroenterology
Volume	118
Issue number	9
DOIs	https://doi.org/10.14309/ajg.0000000000002317
State	Published - 1 Sep 2023
Externally published	Yes

Keywords

celiac disease
COVID-19
SARS-CoV-2
screening

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10.14309/ajg.0000000000002317

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title = "Previous SARS-CoV-2 Infection Is Not Associated with Increased Celiac Disease Autoimmunity in Children and Adolescents",

abstract = "INTRODUCTION:Recent reports suggest severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections may increase the risk of celiac disease autoimmunity. This study aims to evaluate potential associations between coronavirus disease 2019 infection and tissue transglutaminase autoantibodies (TGA) immunoglobulin A.METHODS:From 2020 to 2021, cross-sectional screening for SARS-CoV-2 antibodies and TGA was offered to 4,717 children in Colorado through the Autoimmunity Screening for Kids study. Multivariable logistic regression assessed association between previous SARS-CoV-2 infection and TGA positivity.RESULTS:Previous SARS-CoV-2 infection was not associated with TGA positivity (odds ratio 1.02, 95\% confidence interval 0.63-1.59; P = 0.95).DISCUSSION:In this large-scale analysis, previous SARS-CoV-2 infection was not associated with celiac disease autoimmunity in Colorado children.",

keywords = "celiac disease, COVID-19, SARS-CoV-2, screening",

author = "Corrado, \{Michelle M.\} and Xiaofan Jia and \{Geno Rasmussen\}, Cristy and Laura Pyle and Liping Yu and Edwin Liu and Marisa Stahl and Rewers, \{Marian J.\}",

year = "2023",

month = sep,

day = "1",

doi = "10.14309/ajg.0000000000002317",

language = "English",

volume = "118",

pages = "1698--1700",

journal = "American Journal of Gastroenterology",

issn = "0002-9270",

publisher = "Wolters Kluwer Health",

number = "9",

}

TY - JOUR

T1 - Previous SARS-CoV-2 Infection Is Not Associated with Increased Celiac Disease Autoimmunity in Children and Adolescents

AU - Corrado, Michelle M.

AU - Jia, Xiaofan

AU - Geno Rasmussen, Cristy

AU - Pyle, Laura

AU - Yu, Liping

AU - Liu, Edwin

AU - Stahl, Marisa

AU - Rewers, Marian J.

PY - 2023/9/1

Y1 - 2023/9/1

N2 - INTRODUCTION:Recent reports suggest severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections may increase the risk of celiac disease autoimmunity. This study aims to evaluate potential associations between coronavirus disease 2019 infection and tissue transglutaminase autoantibodies (TGA) immunoglobulin A.METHODS:From 2020 to 2021, cross-sectional screening for SARS-CoV-2 antibodies and TGA was offered to 4,717 children in Colorado through the Autoimmunity Screening for Kids study. Multivariable logistic regression assessed association between previous SARS-CoV-2 infection and TGA positivity.RESULTS:Previous SARS-CoV-2 infection was not associated with TGA positivity (odds ratio 1.02, 95% confidence interval 0.63-1.59; P = 0.95).DISCUSSION:In this large-scale analysis, previous SARS-CoV-2 infection was not associated with celiac disease autoimmunity in Colorado children.

AB - INTRODUCTION:Recent reports suggest severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections may increase the risk of celiac disease autoimmunity. This study aims to evaluate potential associations between coronavirus disease 2019 infection and tissue transglutaminase autoantibodies (TGA) immunoglobulin A.METHODS:From 2020 to 2021, cross-sectional screening for SARS-CoV-2 antibodies and TGA was offered to 4,717 children in Colorado through the Autoimmunity Screening for Kids study. Multivariable logistic regression assessed association between previous SARS-CoV-2 infection and TGA positivity.RESULTS:Previous SARS-CoV-2 infection was not associated with TGA positivity (odds ratio 1.02, 95% confidence interval 0.63-1.59; P = 0.95).DISCUSSION:In this large-scale analysis, previous SARS-CoV-2 infection was not associated with celiac disease autoimmunity in Colorado children.

KW - celiac disease

KW - COVID-19

KW - SARS-CoV-2

KW - screening

UR - https://www.scopus.com/pages/publications/85169187466

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DO - 10.14309/ajg.0000000000002317

M3 - Article

C2 - 37159249

AN - SCOPUS:85169187466

SN - 0002-9270

VL - 118

SP - 1698

EP - 1700

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

IS - 9

ER -

Previous SARS-CoV-2 Infection Is Not Associated with Increased Celiac Disease Autoimmunity in Children and Adolescents

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