Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions

James P. Franciosi; Edward B. Mougey; Evan S. Dellon; Carolina Gutierrez-Junquera; Sonia Fernandez-Fernandez; Rajitha D. Venkatesh; Sandeep K. Gupta

doi:10.2147/JAA.S274524

Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions

James P. Franciosi
, Edward B. Mougey
, Evan S. Dellon
, Carolina Gutierrez-Junquera
, Sonia Fernandez-Fernandez
, Rajitha D. Venkatesh
, Sandeep K. Gupta

Nemours Children's Health System
University of Central Florida
Alfred I. duPont Hospital for Children
University of North Carolina at Chapel Hill
Universidad Autónoma de Madrid
Hospital Severo Ochoa
Nationwide Children’s Hospital
Indiana University Bloomington

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive esophageal eosinophilia (PPI-REE), to a therapy for EoE. This transition resulted from the Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the Appraisal of Guidelines for Research and Evaluation II (AGREE) Conference to support PPI therapy for EoE in children and adults. Additional recent advances have suggested a role for genetic variations that might impact response to PPI therapy for EoE. This review article will explore a brief background of EoE, the evolution of PPI therapy for EoE and its proposed mechanisms, efficacy and safety in children and adults, and considerations for future PPI precision medicine in patients with EoE.

Original language	English
Pages (from-to)	281-302
Number of pages	22
Journal	Journal of Asthma and Allergy
Volume	15
DOIs	https://doi.org/10.2147/JAA.S274524
State	Published - 2022
Externally published	Yes

Keywords

EoE
Eosinophilic esophagitis
PPI
Precision medicine
Proton pump inhibitor medication

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10.2147/JAA.S274524

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@article{1776b3c359654aaf8d0334b126ce56a3,

title = "Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions",

abstract = "Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive esophageal eosinophilia (PPI-REE), to a therapy for EoE. This transition resulted from the Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the Appraisal of Guidelines for Research and Evaluation II (AGREE) Conference to support PPI therapy for EoE in children and adults. Additional recent advances have suggested a role for genetic variations that might impact response to PPI therapy for EoE. This review article will explore a brief background of EoE, the evolution of PPI therapy for EoE and its proposed mechanisms, efficacy and safety in children and adults, and considerations for future PPI precision medicine in patients with EoE.",

keywords = "EoE, Eosinophilic esophagitis, PPI, Precision medicine, Proton pump inhibitor medication",

author = "Franciosi, \{James P.\} and Mougey, \{Edward B.\} and Dellon, \{Evan S.\} and Carolina Gutierrez-Junquera and Sonia Fernandez-Fernandez and Venkatesh, \{Rajitha D.\} and Gupta, \{Sandeep K.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Franciosi et al.",

year = "2022",

doi = "10.2147/JAA.S274524",

language = "English",

volume = "15",

pages = "281--302",

journal = "Journal of Asthma and Allergy",

issn = "1178-6965",

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T1 - Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis

T2 - History, Mechanisms, Efficacy, and Future Directions

AU - Franciosi, James P.

AU - Mougey, Edward B.

AU - Dellon, Evan S.

AU - Gutierrez-Junquera, Carolina

AU - Fernandez-Fernandez, Sonia

AU - Venkatesh, Rajitha D.

AU - Gupta, Sandeep K.

PY - 2022

Y1 - 2022

N2 - Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive esophageal eosinophilia (PPI-REE), to a therapy for EoE. This transition resulted from the Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the Appraisal of Guidelines for Research and Evaluation II (AGREE) Conference to support PPI therapy for EoE in children and adults. Additional recent advances have suggested a role for genetic variations that might impact response to PPI therapy for EoE. This review article will explore a brief background of EoE, the evolution of PPI therapy for EoE and its proposed mechanisms, efficacy and safety in children and adults, and considerations for future PPI precision medicine in patients with EoE.

AB - Over the past decade, the role of proton pump inhibitor (PPI) medication has evolved from a diagnostic tool for Eosinophilic Esophagitis (EoE), by excluding patients with PPI responsive esophageal eosinophilia (PPI-REE), to a therapy for EoE. This transition resulted from the Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the Appraisal of Guidelines for Research and Evaluation II (AGREE) Conference to support PPI therapy for EoE in children and adults. Additional recent advances have suggested a role for genetic variations that might impact response to PPI therapy for EoE. This review article will explore a brief background of EoE, the evolution of PPI therapy for EoE and its proposed mechanisms, efficacy and safety in children and adults, and considerations for future PPI precision medicine in patients with EoE.

KW - EoE

KW - Eosinophilic esophagitis

KW - PPI

KW - Precision medicine

KW - Proton pump inhibitor medication

UR - https://www.scopus.com/pages/publications/85125656459

U2 - 10.2147/JAA.S274524

DO - 10.2147/JAA.S274524

M3 - Review article

AN - SCOPUS:85125656459

SN - 1178-6965

VL - 15

SP - 281

EP - 302

JO - Journal of Asthma and Allergy

JF - Journal of Asthma and Allergy

ER -

Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions

Abstract

Keywords

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