Sensitivity of Two-Tiered Lyme Disease Serology in Children With an Erythema Migrans Lesion

Amy D. Thompson; Fran Balamuth; Desiree N. Neville; Laura L. Chapman; Michael N. Levas; Anupam B. Kharbanda; John A. Branda; Meagan M. Ladell; Claire Loiselle; Lise E. Nigrovic

doi:10.1093/jpids/piad073

Sensitivity of Two-Tiered Lyme Disease Serology in Children With an Erythema Migrans Lesion

Amy D. Thompson
, Fran Balamuth
, Desiree N. Neville
, Laura L. Chapman
, Michael N. Levas
, Anupam B. Kharbanda
, John A. Branda
, Meagan M. Ladell
, Claire Loiselle
, Lise E. Nigrovic

Thomas Jefferson University
University of Pennsylvania
University of Pittsburgh
Brown University
Children's Hospital of Wisconsin Wauwatosa
Children's Minnesota
Harvard University
Alfred I. duPont Hospital for Children

Research output: Contribution to journal › Article › peer-review

Abstract

In our prospective cohort of 192 children with a physician-diagnosed erythema migrans (EM) lesion, two-tier Lyme disease serology had higher sensitivity in children with multiple EM lesions (76.8% multiple lesions vs. 38.1% single EM; difference 38.7%, 95% confidence interval 24.8%-50.4%). The diagnosis of cutaneous Lyme disease should be based on careful physical examination rather than laboratory testing.

Original language	English
Pages (from-to)	553-555
Number of pages	3
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	12
Issue number	10
DOIs	https://doi.org/10.1093/jpids/piad073
State	Published - 28 Oct 2023
Externally published	Yes

Keywords

Child
Erythema Chronicum Migrans/diagnosis
Humans
Lyme Disease/complications
Prospective Studies

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10.1093/jpids/piad073

Cite this

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title = "Sensitivity of Two-Tiered Lyme Disease Serology in Children With an Erythema Migrans Lesion",

abstract = "In our prospective cohort of 192 children with a physician-diagnosed erythema migrans (EM) lesion, two-tier Lyme disease serology had higher sensitivity in children with multiple EM lesions (76.8\% multiple lesions vs. 38.1\% single EM; difference 38.7\%, 95\% confidence interval 24.8\%-50.4\%). The diagnosis of cutaneous Lyme disease should be based on careful physical examination rather than laboratory testing.",

keywords = "Child, Erythema Chronicum Migrans/diagnosis, Humans, Lyme Disease/complications, Prospective Studies",

author = "Thompson, \{Amy D.\} and Fran Balamuth and Neville, \{Desiree N.\} and Chapman, \{Laura L.\} and Levas, \{Michael N.\} and Kharbanda, \{Anupam B.\} and Branda, \{John A.\} and Ladell, \{Meagan M.\} and Claire Loiselle and Nigrovic, \{Lise E.\}",

year = "2023",

month = oct,

day = "28",

doi = "10.1093/jpids/piad073",

language = "English",

volume = "12",

pages = "553--555",

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AU - Thompson, Amy D.

AU - Balamuth, Fran

AU - Neville, Desiree N.

AU - Chapman, Laura L.

AU - Levas, Michael N.

AU - Kharbanda, Anupam B.

AU - Branda, John A.

AU - Ladell, Meagan M.

AU - Loiselle, Claire

AU - Nigrovic, Lise E.

PY - 2023/10/28

Y1 - 2023/10/28

N2 - In our prospective cohort of 192 children with a physician-diagnosed erythema migrans (EM) lesion, two-tier Lyme disease serology had higher sensitivity in children with multiple EM lesions (76.8% multiple lesions vs. 38.1% single EM; difference 38.7%, 95% confidence interval 24.8%-50.4%). The diagnosis of cutaneous Lyme disease should be based on careful physical examination rather than laboratory testing.

AB - In our prospective cohort of 192 children with a physician-diagnosed erythema migrans (EM) lesion, two-tier Lyme disease serology had higher sensitivity in children with multiple EM lesions (76.8% multiple lesions vs. 38.1% single EM; difference 38.7%, 95% confidence interval 24.8%-50.4%). The diagnosis of cutaneous Lyme disease should be based on careful physical examination rather than laboratory testing.

KW - Child

KW - Erythema Chronicum Migrans/diagnosis

KW - Humans

KW - Lyme Disease/complications

KW - Prospective Studies

UR - https://www.scopus.com/pages/publications/85175356902

U2 - 10.1093/jpids/piad073

DO - 10.1093/jpids/piad073

M3 - Article

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AN - SCOPUS:85175356902

SN - 2048-7193

VL - 12

SP - 553

EP - 555

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

IS - 10

ER -

Sensitivity of Two-Tiered Lyme Disease Serology in Children With an Erythema Migrans Lesion

Abstract

Keywords

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