The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children

Brittany N. Simpson; Miguel E. Mejía Sang; Yonairy Collado Puello; Elvira J. Diaz Brockmans; María F. Díaz Soto; Stephanie M. Rivera Defilló; Karla M. Taveras Cruz; Javier O. Santiago Pérez; Ammar Husami; Melissa E. Day; Valentina Pilipenko; Rafael Mena; Cesár Mota; Margaret K. Hostetter; Louis J. Muglia; Elizabeth Schlaudecker; Javier Gonzalez del Rey; Lisa J. Martin; Carlos E. Prada

doi:10.1093/jpids/piac136

The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children

Brittany N. Simpson
, Miguel E. Mejía Sang
, Yonairy Collado Puello
, Elvira J. Diaz Brockmans
, María F. Díaz Soto
, Stephanie M. Rivera Defilló
, Karla M. Taveras Cruz
, Javier O. Santiago Pérez
, Ammar Husami
, Melissa E. Day
, Valentina Pilipenko
, Rafael Mena
, Cesár Mota
, Margaret K. Hostetter
, Louis J. Muglia
, Elizabeth Schlaudecker
, Javier Gonzalez del Rey
, Lisa J. Martin
, Carlos E. Prada

Cincinnati Children's Hospital Medical Center
University of Cincinnati
Santo Domingo Institute of Technology
Universidad Iberoamericana, Santo Domingo
Centro de Obsetricia y Ginecologia
Hospital Infantil Dr. Robert Reid
Burroughs Welcome Fund
Children's Memorial Hospital
Northwestern University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.

Original language	English
Pages (from-to)	169-172
Number of pages	4
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	12
Issue number	3
DOIs	https://doi.org/10.1093/jpids/piac136
State	Published - 18 Apr 2023
Externally published	Yes

Keywords

Child
Cohort Studies
Dengue/diagnosis
Dominican Republic/epidemiology
Genomics
Humans
Severe Dengue

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10.1093/jpids/piac136

Cite this

Simpson, B. N., Mejía Sang, M. E., Puello, Y. C., Diaz Brockmans, E. J., Díaz Soto, M. F., Rivera Defilló, S. M., Taveras Cruz, K. M., Santiago Pérez, J. O., Husami, A., Day, M. E., Pilipenko, V., Mena, R., Mota, C., Hostetter, M. K., Muglia, L. J., Schlaudecker, E., del Rey, J. G., Martin, L. J., & Prada, C. E. (2023). The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children. Journal of the Pediatric Infectious Diseases Society, 12(3), 169-172. https://doi.org/10.1093/jpids/piac136

@article{d0df57fd96cf47a0879658f50b01266a,

title = "The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children",

abstract = "We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.",

keywords = "Child, Cohort Studies, Dengue/diagnosis, Dominican Republic/epidemiology, Genomics, Humans, Severe Dengue",

author = "Simpson, \{Brittany N.\} and \{Mej{\'i}a Sang\}, \{Miguel E.\} and Puello, \{Yonairy Collado\} and \{Diaz Brockmans\}, \{Elvira J.\} and \{D{\'i}az Soto\}, \{Mar{\'i}a F.\} and \{Rivera Defill{\'o}\}, \{Stephanie M.\} and \{Taveras Cruz\}, \{Karla M.\} and \{Santiago P{\'e}rez\}, \{Javier O.\} and Ammar Husami and Day, \{Melissa E.\} and Valentina Pilipenko and Rafael Mena and Ces{\'a}r Mota and Hostetter, \{Margaret K.\} and Muglia, \{Louis J.\} and Elizabeth Schlaudecker and \{del Rey\}, \{Javier Gonzalez\} and Martin, \{Lisa J.\} and Prada, \{Carlos E.\}",

note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected].",

year = "2023",

month = apr,

day = "18",

doi = "10.1093/jpids/piac136",

language = "English",

volume = "12",

pages = "169--172",

journal = "Journal of the Pediatric Infectious Diseases Society",

issn = "2048-7193",

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}

Simpson, BN, Mejía Sang, ME, Puello, YC, Diaz Brockmans, EJ, Díaz Soto, MF, Rivera Defilló, SM, Taveras Cruz, KM, Santiago Pérez, JO, Husami, A, Day, ME, Pilipenko, V, Mena, R, Mota, C, Hostetter, MK, Muglia, LJ, Schlaudecker, E, del Rey, JG, Martin, LJ & Prada, CE 2023, 'The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children', Journal of the Pediatric Infectious Diseases Society, vol. 12, no. 3, pp. 169-172. https://doi.org/10.1093/jpids/piac136

TY - JOUR

T1 - The 2019-2020 Dengue Fever Epidemic

T2 - Genomic Markers Indicating Severity in Dominican Republic Children

AU - Simpson, Brittany N.

AU - Mejía Sang, Miguel E.

AU - Puello, Yonairy Collado

AU - Diaz Brockmans, Elvira J.

AU - Díaz Soto, María F.

AU - Rivera Defilló, Stephanie M.

AU - Taveras Cruz, Karla M.

AU - Santiago Pérez, Javier O.

AU - Husami, Ammar

AU - Day, Melissa E.

AU - Pilipenko, Valentina

AU - Mena, Rafael

AU - Mota, Cesár

AU - Hostetter, Margaret K.

AU - Muglia, Louis J.

AU - Schlaudecker, Elizabeth

AU - del Rey, Javier Gonzalez

AU - Martin, Lisa J.

AU - Prada, Carlos E.

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected].

PY - 2023/4/18

Y1 - 2023/4/18

N2 - We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.

AB - We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.

KW - Child

KW - Cohort Studies

KW - Dengue/diagnosis

KW - Dominican Republic/epidemiology

KW - Genomics

KW - Humans

KW - Severe Dengue

UR - https://www.scopus.com/pages/publications/85147865123

U2 - 10.1093/jpids/piac136

DO - 10.1093/jpids/piac136

M3 - Article

C2 - 36537278

AN - SCOPUS:85147865123

SN - 2048-7193

VL - 12

SP - 169

EP - 172

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

IS - 3

ER -

The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children

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Keywords

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