Treatment of Rejection in Vascularized Composite Allotransplantation

Muayyad Alhefzi; Mario A. Aycart; Ericka M. Bueno; Harriet Kiwanuka; Nicco Krezdorn; Bohdan Pomahac; Stefan G. Tullius

doi:10.1007/s40472-016-0128-3

Treatment of Rejection in Vascularized Composite Allotransplantation

Muayyad Alhefzi
, Mario A. Aycart
, Ericka M. Bueno
, Harriet Kiwanuka
, Nicco Krezdorn
, Bohdan Pomahac
, Stefan G. Tullius

Harvard University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Vascularized composite allotransplantation (VCA) has become an important modality to restore disfigured parts of the body that cannot be restored with conventional reconstructive techniques. Reported short- and long-term functional and esthetic outcomes have been excellent. However, acute rejection remains the most common complication associated with VCA. In addition, recent reports have linked the loss of some allografts to chronic rejections potentially fueled by insufficiently treated acute rejections. Here, we highlight recent diagnostic and therapeutic strategies for the prevention and treatment of acute and chronic rejections in VCA.

Original language	English
Pages (from-to)	404-409
Number of pages	6
Journal	Current Transplantation Reports
Volume	3
Issue number	4
DOIs	https://doi.org/10.1007/s40472-016-0128-3
State	Published - 1 Dec 2016
Externally published	Yes

Keywords

Acute rejection
Chronic rejection
Face transplantation
Hand transplantation
Vascularized composite allotransplant

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10.1007/s40472-016-0128-3

Cite this

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title = "Treatment of Rejection in Vascularized Composite Allotransplantation",

abstract = "Vascularized composite allotransplantation (VCA) has become an important modality to restore disfigured parts of the body that cannot be restored with conventional reconstructive techniques. Reported short- and long-term functional and esthetic outcomes have been excellent. However, acute rejection remains the most common complication associated with VCA. In addition, recent reports have linked the loss of some allografts to chronic rejections potentially fueled by insufficiently treated acute rejections. Here, we highlight recent diagnostic and therapeutic strategies for the prevention and treatment of acute and chronic rejections in VCA.",

keywords = "Acute rejection, Chronic rejection, Face transplantation, Hand transplantation, Vascularized composite allotransplant",

author = "Muayyad Alhefzi and Aycart, \{Mario A.\} and Bueno, \{Ericka M.\} and Harriet Kiwanuka and Nicco Krezdorn and Bohdan Pomahac and Tullius, \{Stefan G.\}",

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AU - Alhefzi, Muayyad

AU - Aycart, Mario A.

AU - Bueno, Ericka M.

AU - Kiwanuka, Harriet

AU - Krezdorn, Nicco

AU - Pomahac, Bohdan

AU - Tullius, Stefan G.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Vascularized composite allotransplantation (VCA) has become an important modality to restore disfigured parts of the body that cannot be restored with conventional reconstructive techniques. Reported short- and long-term functional and esthetic outcomes have been excellent. However, acute rejection remains the most common complication associated with VCA. In addition, recent reports have linked the loss of some allografts to chronic rejections potentially fueled by insufficiently treated acute rejections. Here, we highlight recent diagnostic and therapeutic strategies for the prevention and treatment of acute and chronic rejections in VCA.

AB - Vascularized composite allotransplantation (VCA) has become an important modality to restore disfigured parts of the body that cannot be restored with conventional reconstructive techniques. Reported short- and long-term functional and esthetic outcomes have been excellent. However, acute rejection remains the most common complication associated with VCA. In addition, recent reports have linked the loss of some allografts to chronic rejections potentially fueled by insufficiently treated acute rejections. Here, we highlight recent diagnostic and therapeutic strategies for the prevention and treatment of acute and chronic rejections in VCA.

KW - Acute rejection

KW - Chronic rejection

KW - Face transplantation

KW - Hand transplantation

KW - Vascularized composite allotransplant

UR - https://www.scopus.com/pages/publications/85090082060

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DO - 10.1007/s40472-016-0128-3

M3 - Article

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SN - 2196-3029

VL - 3

SP - 404

EP - 409

JO - Current Transplantation Reports

JF - Current Transplantation Reports

IS - 4

ER -

Treatment of Rejection in Vascularized Composite Allotransplantation

Abstract

Keywords

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