TY - JOUR
T1 - COVID-19 Disease in Children With ALL Receiving Maintenance Therapy
T2 - Do Not Discount the Risk
AU - POCC Consortium
AU - Kahn, Alissa R.
AU - Davis, Elizabeth S.
AU - Dai, Chen
AU - Caudill, Caroline V.
AU - Martinez, Isaac
AU - Brackett, Julienne
AU - Sharma, Archana
AU - Schwalm, Carla
AU - Kebede, Ann
AU - Dickens, David S.
AU - Richman, Joshua
AU - Colace, Susan I.
AU - Araya, Brook
AU - Bhatia, Smita
AU - Wolfson, Julie A.
AU - Levine, Jennifer M.
AU - Johnston, Emily E.
AU - Aftandilian, Catherine
AU - Agrawal, Anurag K.
AU - De Angulo, Guillermo
AU - Aristizabal, Paula
AU - Bailey, Kayleen
AU - Bardwell, Jenna K.
AU - Becton, David L.
AU - Bemrich-Stolz, Christina J.
AU - Boal, Lauren H.
AU - Boston, Catherine W.H.
AU - Bradfield, Scott M.
AU - Caywood, Emi H.
AU - Cohn, Shannon M.
AU - Colace, Susan I.
AU - Coven, Scott L.
AU - Cramer, Stuart L.
AU - Cuglievan, Branko
AU - Dargart, Jamie L.
AU - Daghistani, Doured
AU - Dhir, Aditi
AU - Dickens, David S.
AU - Dumitriu, Anca
AU - Eslin, Don E.
AU - Esquilin, Jose M.
AU - Feinberg, Shari L.
AU - Ferdjallah, Asmaa
AU - Fernandez, Karen S.
AU - Fixler, Jason
AU - Foley, Jessica M.
AU - Gampel, Bradley H.
AU - Glasser, Chana L.
AU - Goodman, Jessica F.
AU - Gotesman, Moran
N1 - Publisher Copyright:
© 2024 by American Society of Clinical Oncology.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - PURPOSE Unlike most childhood cancers, therapy for ALL includes a prolonged maintenance phase during which children typically resume regular activities. Physicians need data regarding the persistent impact of COVID-19 in this population to help guide families after the pandemic. METHODS The Pediatric Oncology COVID-19 Case Report (POCC) collects deidentified data (sociodemographics, clinical data [cancer, COVID-19 course]) on children, adolescents, and young adults with cancer and COVID-19 from 104 US pediatric oncology institutions. The analysis presented here compares children (≤21 years) with ALL in maintenance (ALL-MTN) with all other children with cancer and COVID-19. Multivariable analyses adjust for age, race/ ethnicity, insurance, absolute neutrophil count at the time of infection, vaccination, and comorbidities. RESULTS Compared with other children reported to POCC (n 5 1,190), those in ALL-MTN (n 5 481) were less often hospitalized (23% v 29%, P 5 .01) or admitted to the intensive care unit (ICU: 3% v 5%, P 5 .01); these findings persisted in multivariable analysis (hospitalization: odds ratio [OR], 0.7 [95% CI, 0.6 to 0.9]; ICU: OR, 0.5 [95% CI, 0.2 to 0.8]). However, cancer-directed therapy was changed more often for children in ALL-MTN (50% v 33%, P ≤ .01; OR, 2.0 [95% CI, 1.6 to 2.5[). Vaccination was an independent prognostic factor in our multivariable model, decreasing odds of hospitalization (OR, 0.7 [95% CI, 0.5 to 0.9]). CONCLUSION Children in ALL-MTN required fewer hospitalizations and ICU admissions but more therapy modifications than other children with cancer. Vaccination against COVID-19 reduced the odds of hospitalization.
AB - PURPOSE Unlike most childhood cancers, therapy for ALL includes a prolonged maintenance phase during which children typically resume regular activities. Physicians need data regarding the persistent impact of COVID-19 in this population to help guide families after the pandemic. METHODS The Pediatric Oncology COVID-19 Case Report (POCC) collects deidentified data (sociodemographics, clinical data [cancer, COVID-19 course]) on children, adolescents, and young adults with cancer and COVID-19 from 104 US pediatric oncology institutions. The analysis presented here compares children (≤21 years) with ALL in maintenance (ALL-MTN) with all other children with cancer and COVID-19. Multivariable analyses adjust for age, race/ ethnicity, insurance, absolute neutrophil count at the time of infection, vaccination, and comorbidities. RESULTS Compared with other children reported to POCC (n 5 1,190), those in ALL-MTN (n 5 481) were less often hospitalized (23% v 29%, P 5 .01) or admitted to the intensive care unit (ICU: 3% v 5%, P 5 .01); these findings persisted in multivariable analysis (hospitalization: odds ratio [OR], 0.7 [95% CI, 0.6 to 0.9]; ICU: OR, 0.5 [95% CI, 0.2 to 0.8]). However, cancer-directed therapy was changed more often for children in ALL-MTN (50% v 33%, P ≤ .01; OR, 2.0 [95% CI, 1.6 to 2.5[). Vaccination was an independent prognostic factor in our multivariable model, decreasing odds of hospitalization (OR, 0.7 [95% CI, 0.5 to 0.9]). CONCLUSION Children in ALL-MTN required fewer hospitalizations and ICU admissions but more therapy modifications than other children with cancer. Vaccination against COVID-19 reduced the odds of hospitalization.
UR - https://www.scopus.com/pages/publications/85212589647
U2 - 10.1200/OP.23.00631
DO - 10.1200/OP.23.00631
M3 - Article
C2 - 39159420
AN - SCOPUS:85212589647
SN - 2688-1527
VL - 20
SP - 1655
EP - 1662
JO - JCO Oncology Practice
JF - JCO Oncology Practice
IS - 12
ER -