Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis

Charlene Dekonenko; Jason D. Fraser; Katherine J. Deans; Mary E. Fallat; Michael Helmrath; Rashmi Kabre; Charles M. Leys; R. Cartland Burns; Kristine Corkumd; Patrick A. Dillon; Cynthia Downard; Tiffany N. Wright; Samir K. Gadepalli; Julia E. Grabowski; Edward Hernandez; Ronald Hirschl; Kevin N. Johnson; Jonathan E. Kohler; Matthew P. Landman; Rachel M. Landisch; Amy E. Lawrence; Grace Z. Mak; Peter C. Minneci; Beth Rymeski; Thomas T. Sato; Bethany J. Slater; Shawn D. St. Peter

doi:10.1038/s41372-021-01093-8

Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis

Charlene Dekonenko
, Jason D. Fraser
, Katherine J. Deans
, Mary E. Fallat
, Michael Helmrath
, Rashmi Kabre
, Charles M. Leys
, R. Cartland Burns
, Kristine Corkumd
, Patrick A. Dillon
, Cynthia Downard
, Tiffany N. Wright
, Samir K. Gadepalli
, Julia E. Grabowski
, Edward Hernandez
, Ronald Hirschl
, Kevin N. Johnson
, Jonathan E. Kohler
, Matthew P. Landman
, Rachel M. Landisch

Amy E. Lawrence, Grace Z. Mak, Peter C. Minneci, Beth Rymeski, Thomas T. Sato, Bethany J. Slater, Shawn D. St. Peter

Children's Mercy Hospitals and Clinics
Nationwide Children’s Hospital
University of Louisville
Cincinnati Children's Hospital Medical Center
Northwestern University
University of Wisconsin-Madison
Riley Hospital for Children
Washington University St. Louis
University of Michigan, Ann Arbor
Children's Hospital of Wisconsin Wauwatosa
The University of Chicago

Producción científica › revisión exhaustiva

19 Citas (Scopus)

Resumen

Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.

Idioma original	English
Páginas (desde-hasta)	1755-1759
Número de páginas	5
Publicación	Journal of Perinatology
Volumen	41
N.º	7
DOI	https://doi.org/10.1038/s41372-021-01093-8
Estado	Published - jul 2021
Publicado de forma externa	Sí

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Dekonenko, C., Fraser, J. D., Deans, K. J., Fallat, M. E., Helmrath, M., Kabre, R., Leys, C. M., Burns, R. C., Corkumd, K., Dillon, P. A., Downard, C., Wright, T. N., Gadepalli, S. K., Grabowski, J. E., Hernandez, E., Hirschl, R., Johnson, K. N., Kohler, J. E., Landman, M. P., ... St. Peter, S. D. (2021). Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis. Journal of Perinatology, 41(7), 1755-1759. https://doi.org/10.1038/s41372-021-01093-8

@article{21d69bf18c7a48e6b7d0d3931d6d7538,

title = "Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis",

abstract = "Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children{\textquoteright}s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher{\textquoteright}s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80\%) SG and 79 (20\%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90\% vs 73\%), SSIs (31\% vs 11\%), NEC (14\% vs 6\%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11\% vs 0\%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.",

author = "Charlene Dekonenko and Fraser, \{Jason D.\} and Deans, \{Katherine J.\} and Fallat, \{Mary E.\} and Michael Helmrath and Rashmi Kabre and Leys, \{Charles M.\} and Burns, \{R. Cartland\} and Kristine Corkumd and Dillon, \{Patrick A.\} and Cynthia Downard and Wright, \{Tiffany N.\} and Gadepalli, \{Samir K.\} and Grabowski, \{Julia E.\} and Edward Hernandez and Ronald Hirschl and Johnson, \{Kevin N.\} and Kohler, \{Jonathan E.\} and Landman, \{Matthew P.\} and Landisch, \{Rachel M.\} and Lawrence, \{Amy E.\} and Mak, \{Grace Z.\} and Minneci, \{Peter C.\} and Beth Rymeski and Sato, \{Thomas T.\} and Slater, \{Bethany J.\} and \{St. Peter\}, \{Shawn D.\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

month = jul,

doi = "10.1038/s41372-021-01093-8",

language = "English",

volume = "41",

pages = "1755--1759",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Springer Nature",

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Dekonenko, C, Fraser, JD, Deans, KJ, Fallat, ME, Helmrath, M, Kabre, R, Leys, CM, Burns, RC, Corkumd, K, Dillon, PA, Downard, C, Wright, TN, Gadepalli, SK, Grabowski, JE, Hernandez, E, Hirschl, R, Johnson, KN, Kohler, JE, Landman, MP, Landisch, RM, Lawrence, AE, Mak, GZ, Minneci, PC, Rymeski, B, Sato, TT, Slater, BJ & St. Peter, SD 2021, 'Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis', Journal of Perinatology, vol. 41, n.º 7, pp. 1755-1759. https://doi.org/10.1038/s41372-021-01093-8

TY - JOUR

T1 - Outcomes in gastroschisis

T2 - expectations in the postnatal period for simple vs complex gastroschisis

AU - Dekonenko, Charlene

AU - Fraser, Jason D.

AU - Deans, Katherine J.

AU - Fallat, Mary E.

AU - Helmrath, Michael

AU - Kabre, Rashmi

AU - Leys, Charles M.

AU - Burns, R. Cartland

AU - Corkumd, Kristine

AU - Dillon, Patrick A.

AU - Downard, Cynthia

AU - Wright, Tiffany N.

AU - Gadepalli, Samir K.

AU - Grabowski, Julia E.

AU - Hernandez, Edward

AU - Hirschl, Ronald

AU - Johnson, Kevin N.

AU - Kohler, Jonathan E.

AU - Landman, Matthew P.

AU - Landisch, Rachel M.

AU - Lawrence, Amy E.

AU - Mak, Grace Z.

AU - Minneci, Peter C.

AU - Rymeski, Beth

AU - Sato, Thomas T.

AU - Slater, Bethany J.

AU - St. Peter, Shawn D.

PY - 2021/7

Y1 - 2021/7

N2 - Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.

AB - Objective: To provide generalizable estimates for expected outcomes of simple gastroschisis (SG) and complex gastroschisis (CG) patients from a large multi-institutional cohort for use during counseling. Study design: A retrospective study of 394 neonates with gastroschisis at 11 children’s hospitals from January 2013 to March 2017 was performed. Analysis by Fisher’s exact tests and Wilcoxon rank sum tests were performed. Outcomes of complex and simple gastroschisis are reported. Result: There were 315 (80%) SG and 79 (20%) CG. CG had increased time from birth to closure (6 vs 4.4 days), closure to goal feeds (69 vs 23 days), ventilator use (90% vs 73%), SSIs (31% vs 11%), NEC (14% vs 6%), PN use (71 vs 24 days), LOS (104.5 vs 33 days), and mortality (11% vs 0%). Conclusion: This study provides generalizable estimates for expected outcomes of patients with both SG and CG that can be utilized during counseling. CG has significantly worse in-hospital outcomes.

UR - https://www.scopus.com/pages/publications/85106431685

U2 - 10.1038/s41372-021-01093-8

DO - 10.1038/s41372-021-01093-8

M3 - Article

C2 - 34035447

AN - SCOPUS:85106431685

SN - 0743-8346

VL - 41

SP - 1755

EP - 1759

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 7

ER -

Outcomes in gastroschisis: expectations in the postnatal period for simple vs complex gastroschisis

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