Rosai-Dorfman Disease of the breast in a 13-year-Old female: A case report

Introduction: Rosai-Dorfman Disease (RDD) is reactive histiocytic disorder, which rarely occurs in the breast. Typically, it presents in women during their 5th decade of life, for which it is often confused with malignancy. Very few reports have reported its occurrence in the younger population, particularly pediatric patients. Case presentation: A 13-year-old female presented with a painful 3-cm mass the upper quadrant of the left breast. Ultrasound showed a hypoechoic mass with irregular margins abutting the skin, reported as a BI-RADS 5 lesion. Excisional biopsy of the mass showed Rosai Dorfman disease of the breast with involved margins. Follow-up PET/CT did not show any residual FDG-avid regions in the breast. Conclusion: RDD should remain in the differential diagnosis for breast masses for teenage patients, as we report the youngest known case of RDD of the breast.